Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D₃, is a form of vitamin D produced in the liver by hydroxylation of vitamin D₃ by the enzyme vitamin D 25-hydroxylase.
Calcifediol, also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D₃, is a form of vitamin D produced in the liver by hydroxylation of vitamin D₃ by the enzyme vitamin D 25-hydroxylase.
1.25% 25-hydroxyvitamin D₃
| Product | 25-Hydroxy Vitamin D3 | Batch No | 2203091 |
| Specification | ≥1.25% | Quantity | 1000kg |
| Mfg. Date | 2022.03.09 | Issu. Date | 2022.03.10 |
| Exp. Date | 2024.03.08 | Packing | 25kg/carton |
| Quality Standard | Q/JLBO 11-2021 | ||
| Items | Specification | Results | |
| [Appearance and character] | white to yellow powder | White powder | |
| [Examining! | |||
| Granularity | 100.0% pass through the sieve of 0.85mm； More than 85.0% pass through the sieve of 0.425mm | 100.0% pass through the sieve of 0.85mm； 90.3% pass through the sieve of 0.425mm. | |
| Loss on drying | ≤5.0% | 3.1% | |
| Heavy metals | ≤5mg/kg | Complies | |
| Total Arsenic | ≤3mg/kg | Complies | |
| [Assay] | Contains 25-Hydroxy Vitamin D3 31.25% | 1.31% | |
| Conclusion: The result meets the requirements of Q/JLBO11 -202 | |||
0.025% 25-hydroxyvitamin D₃
| Product | 25-Hydroxy Vitamin D3 | Batch No | 2203132 |
| Specification | ≥0.025% | Quantity | 1000kg |
| Mfg. Date | 2022.03.13 | Issu. Date | 2022.03.14 |
| Exp. Date | 2024.03.12 | Packing | 25kg/carton |
| Quality Standard | Q/JLB011-2021 | ||
| Items | Specification | Results | |
| [Appearance and character] | white to yellow powder | White powder | |
| [Examining] | |||
| Granularity | 100.0% pass through the sieve of 0.85mm； More than 85.0% pass through the sieve of 0.425mm | 100.0% pass through the sieve of 0.85mm； 90.3% pass through the sieve of 0.425mm. | |
| Loss on drying | ≤5.0% | 0.8% | |
| Heavy metals | ≤5mg/kg | Complies | |
| Total Arsenic | ≤3mg/kg | Complies | |
| [Assay] | Contains 25-Hydroxy Vitamin D3 30.025% | 002^%— | |
| Conclusion: The result meets the requirements of | |||
25-hydroxyvitamin D3 have been used in some studies to improve vitamin D status. Indications for their use include vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia, hypoparathyroidism, hypocalcemia and renal osteodystrophy and, with calcium, in primary or corticosteroid-induced osteoporosis.
Calcifediol may have advantages over cholecalciferol for the correction of vitamin D deficiency states. Calcifediol is better absorbed from the intestine and has greater affinity for the vitamin-D-binding protein, both of which increase its bioavailability.
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