Enramycin Premix 8%(Swine)

Molecular formula of enramycin: C107H138N26O31C12, or C108H140N26O31C12. The melting point is 226°C. It turns brown after melting, decomposes at 234-238°C, and is alkaline. It is easily soluble in dilute hydrochloric acid, soluble in water, methanol, and dilute alcohol in Chemicalbook, insoluble in ethanol and acetone, and insoluble in near-neutral buffers. It is stable in dry state, the aqueous solution is stable when the pH value is 3.5-7.5, very stable when pH<3, and extremely unstable when pH>9.

Mechanism of action:
Pharmacodynamic studies:
Enramycin has a strong effect on Gram-positive bacteria. The main mechanism is to inhibit the synthesis of bacterial cell walls and cause cell wall defects, resulting in increased intracellular osmotic pressure and extracellular fluid infiltration into the bacteria. , causing the bacteria to deform and swell, rupture and die. Enramycin mainly acts on the fission stage of bacteria, not only killing bacteria, but also lysing bacteria. Enramycin has strong antibacterial activity against pathogens such as Clostridium difficile, streptococcus, staphylococcus, pneumococcus and other harmful intestinal bacteria.

Toxicological studies
Enramycin toxicity is very low. Acute toxicity experiments show that enramycin is practically non-toxic when administered orally, subcutaneously or intramuscularly. Enramycin has no mutagenic and teratogenic effects. The results of safety studies on target animals showed that oral administration of enramycin is safe.

The drug residue
test showed that the blood concentration of enramycin reached the peak value about 6 hours after intramuscular injection, then gradually decreased, and there was still a considerable amount of drug in the blood after 24 hours. Because the drug that enters the body is excreted slowly, has a long residual period in the tissue, has adverse effects on liver and kidney functions, and can cause inflammatory reactions such as pain and redness at the injection site, so it is clinically used for oral administration and injection is prohibited.
Oral administration of enramycin is extremely difficult to be absorbed, and the drug is mainly excreted through feces. Relevant experimental results show that after animals are directly administered enramycin, the concentration of enramycin in the blood is lower than the detection limit (0.15 μg/g). Drug residues in any tissue of broiler chicken or pig were lower than the detection limit (0.15μg/g).

1) Adding a small amount of enramycin in the feed can promote growth and significantly increase feed remuneration.
2) Enramycin can show good antibacterial effect on Gram-positive bacteria under both aerobic and anaerobic conditions. Enramycin has a strong effect on Clostridium perfringens, which is the main cause of growth inhibition and necrotic enteritis in pigs and chickens.
3) There is no cross-resistance to enramycin.
4) Resistance to enramycin is very slow, and Clostridium perfringens resistant to enramycin has not been isolated yet.
5) Because enramycin is not absorbed in the intestine, there is no need to worry about drug residue and there is no withdrawal period.
6) Enramycin is stable in feed and remains active even in the process of processing pellets.
7) Enramycin can reduce chicken manure.
8) Enramycin can inhibit ammonia-producing microorganisms, so it can reduce the concentration of ammonia in the intestines and blood of pigs and chickens, thereby reducing the concentration of ammonia in livestock houses.
9) Enramycin can alleviate the clinical symptoms of coccidiosis, which may be due to the strong inhibitory effect of enramycin on anaerobic bacteria secondary to infection.

Store in dry conditions below 30º C, away from sunlight. After opening, it should be stored in a separate package.

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