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What are the alternatives to antibiotics in feed

View: 70 Author: Site Editor Publish Time: 2022-07-25 Origin: site

In the past decades of adding antibiotics to feed, scientists have long realized the drawbacks of it. In order to realize the prohibition of antibiotics as soon as possible, they have been concentrating on researching antibiotic feed additives, so that they can contribute to the industry when the real antibiotics are banned. Choose to add.

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By searching for authoritative magazines in major industries, the editor has listed some useful feed additives for antibiotics, hoping to provide reference for breeding friends when choosing antibiotics products or antibiotic-free feeds!


At present, probiotic preparations, antibacterial lipopeptides, plant extracts, zeolites, acidifiers, curcumin, Ural licorice, Acanthopanax senticosus, Zhonglian fatty acids, etc. have been used to replace antibiotics.


Probiotics, antimicrobial lipopeptides, acidulants


A study by Liu Huchuan of the Chinese Academy of Agricultural Sciences found that probiotic preparations can improve the growth performance of weaned piglets, enhance the immunity of early weaned piglets, and effectively alleviate the decline in immune function of piglets caused by early weaning stress. At the same time, improving the impact of weaning stress on the intestinal structure and reducing the intestinal pH can alleviate the impact of weaning stress on the intestinal environment. As the saying goes, raising pigs means raising the intestines, and if the intestines are healthy, the pigs can be raised well. Overall, probiotics have a positive effect on the anti-antibiotics.


Antimicrobial lipopeptide is an important component of the host disease defense system and an effector molecule of innate immunity. It can now be isolated from organisms and is one of the options for alternative antibodies.


Research by Du Haiming of Nanjing Agricultural University found that adding 4000 U/kg antimicrobial lipopeptide can significantly improve the weight gain and digestive enzyme activity of broilers, and adding 12000 U/kg can significantly improve amylase activity and apparent fat digestibility. Antimicrobial lipopeptides can significantly improve piglet growth performance, reduce weaning diarrhea, inhibit Escherichia coli and improve Lactobacillus populations.


The potential of acidifiers to replace the resistance is also particularly obvious. Acidifiers can alleviate the damage of the small intestinal mucosa of piglets, thereby reducing diarrhea, and improving the daily weight gain, feed intake and feed reward of weaned piglets. Studies by Henry et al. have shown that adding acidifiers to the diet can improve piglet growth performance and reduce the rate of diarrhea.


Chen Daiwen's research reported that acidifiers can improve the microbial flora of weaned piglets and enhance their immune function.


plant extracts


Plant extracts are more and more developed for antibacterial products because of their anti-oxidant, immunity-enhancing, bacteriostatic and antibacterial properties, promoting digestion, improving intestinal health, improving production performance and animal product quality.


Fang et al. found that the addition of Acanthopanax senticosus extract can increase the co-migration density of beneficial bacteria Lactobacillus amylovora, Lactobacillus salivarius, Bacillus subtilis, and Clostridium, and reduce harmful bacteria Staphylococcus aureus and Salmonella typhimurium. , Ruminococcus and Escherichia coli co-migrated to the colony density, which can significantly reduce the diarrhea rate of piglets.


Liu et al. studied the effect of pepper oleoresin, garlic and turmeric oleoresin extracts on porcine PRRS.


Alfajaro et al. studied the inhibitory effect of Ural licorice extract on piglet rotavirus diarrhea. The highest dose ( 400mg/mL ) group cured the diarrhea of piglets challenged with porcine rotavirus and improved the small intestinal tissue damage.


Mineral additives


In addition to plant-based additives, mineral-based additives also have considerable antibacterial value. Among them, zeolite has obvious bactericidal effect on Salmonella and Escherichia coli. 1985 . Japan's Hayakawa Shotaro added medical stone to growing pig feed and unexpectedly gained weight gain, which made medical stone attract widespread attention in the animal breeding industry.


medium chain fatty acids


Medium-chain fatty acids ( MCFAs ) are known to have excellent antibacterial properties. For this reason, MCFAs have been widely used as an alternative to antibiotics in animal husbandry, especially in young piglet nutrition.


Han et al. showed that medium-chain fatty acids ( a mixture of caprylic acid and caproic acid ) significantly increased daily gain and daily feed intake of piglets, and in the absence of antibiotics or zinc oxide, the addition of medium-chain fatty acids could enable piglets to use antibiotics. and zinc oxide growth performance in piglets.


The above are just some of the alternative anti-feed additives, only for reference of farmers and friends who love to learn!