New progress has been made in the study of plant extracts regulating the intestinal health of broilers
Recently, the poultry nutrition research team of the Institute of Animal Science, Guangdong Academy of Agricultural Sciences, and the quality control and multi-omics technology innovation team of the Agricultural Biogene Research Center have made new progress in the research on the regulation of intestinal health of broiler chickens by plant extracts. Related research was published in Food & Function. Associate Researcher Ruan Dong is the first author of the paper, and Researcher Jiang Shouqun is the corresponding author. The team of Yan Shijuan, a researcher at the Agricultural Biological Gene Research Center of the Guangdong Academy of Agricultural Sciences, provided important technical support for this study.
Gastrointestinal dysfunction is often accompanied by dysregulation of immune homeostasis, changes in the gut microbiome, and altered bile acid metabolism. Bile acid is the final product of cholesterol decomposition in the liver and is an important regulator of intestinal epithelial barrier function. It mainly regulates energy metabolism and immune function through farnesoid X receptors and G protein-coupled receptors (GPCRs). Type 3 innate lymphocytes (ILC3s) are mainly distributed in the lamina propria of the small intestinal mucosa and are critical for coordinating immunity, inflammation, and tissue homeostasis.
Curcumin is a natural phenolic compound extracted from the ginger plant turmeric (Curcumin longa), which has immunomodulatory, anti-inflammatory, antibacterial and antioxidant properties. The research team's previous studies have shown that curcumin can target intestinal microbes to regulate cellular energy metabolism and mitochondrial homeostasis, and regulate intestinal mucosal immune function, but the mechanism by which curcumin regulates bile acid metabolism and ILC3s function is still unclear.
The researchers screened and analyzed differential metabolites related to curcumin involved in bile acid metabolism and cellular energy metabolism through microbial diversity sequencing and metabolomics, and found that curcumin can regulate the structure of intestinal flora and increase intestinal free Bile acids such as chenodeoxycholic acid, lithocholic acid and butyric acid, 3-hydroxybutyric acid, malic acid and other substances, activate intestinal farnesoid X receptor and GPC RC5A transcriptional expression, accompanied by ILC3s-derived Increased secretion of IL-22 promotes intestinal epithelial barrier repair.
In addition, curcumin can effectively improve lipopolysaccharide-induced mitochondrial dysfunction and inflammatory response by regulating the silent information regulator Sirtuin. Studies have shown that curcumin can act as a modulator of intestinal microbiota to improve intestinal health and immune homeostasis, and this beneficial effect may be related to its participation in the regulation of bile acid-farnesoid X receptor pathway and ILC3s function.
This study provides a scientific basis for curcumin as an immune modulator and health promoter.