Introduction and Application of Antibiotic Feed Additive Macleaya Cordata Extract

1. Introduction of  Macleaya Cordata

Macleaya Cordata extract  is extracted and purified from Macleaya Cordata fruit cheeks. It can be used as a feed additive and biological pesticide. As a feed additive, it can replace antibiotics and is a pure natural feed additive.

Studies at home and abroad have shown that Macleaya Cordata extract with sanguinarine as the main active ingredient has been used in livestock and poultry breeding, which has the effect of improving animal growth performance, and can treat gastrointestinal diseases, including abdominal pain, diarrhea and intestinal Inflammation etc.

2. The application of Macleaya Cordata extract in animal production

1). Macleaya Cordata extract with porcine

Adding Macleaya Cordata extract to the diet of weaned piglets can significantly increase the average daily feed intake and average daily gain of piglets, and reduce the feed-to-weight ratio of piglets. At the same time, adding Macleaya Cordata extract to the diet can effectively prevent The occurrence of piglet diarrhea and increase the apparent digestibility of crude protein, its growth-promoting effect is equivalent to that of aureomycin or oxytetracycline. Macleaya Cordata extract can increase the serum immunoglobulin G (IgG) content and lysozyme (LSZ) activity of weaned piglets, increase the phagocytosis index of macrophages, improve immune function, thereby enhancing the disease resistance of weaned piglets and improving growth performance. Macleaya Cordata extract can also significantly reduce the levels of serum haptoglobin and serum amyloid A in weaned piglets, and has the effect of improving the anti-stress ability.

Adding sanguinarine without tryptophan to low-protein diets of piglets will relatively increase the portal vein plasma flow rate, increase the net absorption of essential amino acids and total amino acids in the portal vein, but will not affect the net absorption of blood urea nitrogen in the portal vein. Adding Macleaya Cordata extract to the diet of fattening pigs can not only improve the feed conversion rate, but also reduce the acute and chronic pathological damage caused by Lawsonia intracellulare infection. In addition, it can also improve the meat color and meat pH before slaughter. Reduce drip loss and improve meat quality. Adding Macleaya Cordata extract to the sow's lactation feed can improve the stress state of the sow, increase the lactation volume of the sow, and increase the weaning weight of the piglet.

2). Macleaya Cordata extract with poultry

Adding Macleaya Cordata extract to the diet of white-feathered broiler chickens can increase the average daily gain, feed conversion rate and average daily feed intake of broilers, and adding Macleaya Cordata extract to the diet with a low crude protein level (18.8%) Compared with the diet with normal crude protein level (19.7%), it can achieve the same average 8 weight gain and average daily feed intake. In addition, Macleaya Cordata  extract can also improve the relative organ weight, serum cholesterol content, intestinal flora and meat quality of white-feathered broilers, reduce the feed-to-weight ratio of broilers and the expression of NO synthase in the jejunum, reduce abdominal fat content, improve Immune system, improve Newcastle disease antibody level, increase slaughter rate and weight gain, increase leg muscle rate, reduce pathogenic bacteria in broiler digestive tract, and improve animal intestinal health. The combined use of Macleaya Cordata extract and organic acid has a better effect on improving the growth performance of broiler chickens.

Macleaya Cordata extract is used as a feed additive in yellow-feathered broilers, which can improve digestion performance, increase average daily feed intake and average daily gain, reduce feed-to-weight ratio, improve European efficiency index, and improve yellow-feathered broiler jejunum food intake. Increase the number of Lactobacillus, increase the ratio of villi height to crypt depth, increase the ratio of breast muscle and leg muscle, reduce the content of MDA in breast muscle after refrigeration, improve carcass quality, and extend the storage period. The use of sanguinarine in low-protein diets for laying hens can improve cellular and humoral immunity, inhibit and reduce the number of E. coli and Salmonella in the ileum, and increase the ratio of villus height to crypt depth, thereby improving the intestinal health of laying hens .

3) Bo drop back extract with aquatic animals

Macleaya Cordata extract has a growth-promoting effect on red tilapia, carp and Caspian sea bream, which can increase the average daily gain, reduce the ratio of feed to weight, and improve the fatness. E has a synergistic effect. Sanguinarine can reduce the total number of bacteria and Escherichia coli in the intestinal tract of carp, and improve the resistance of carp to Aeromonas hydrophila [60;

In crucian carp, sanguinarine can improve the immunity and disease resistance of crucian carp, and up-regulate interleukin-8 (IL-8), interleukin 1β-1 (IL-1β-1), The levels of interleukin 1β-2 (IL-1B-2), tumor necrosis factor a-1 (TNFa-1 ) and tumor necrosis factor a-2 (TNFa-2), decreased chemokine-1 ( CCL-1) mRNA expression, while increasing the expression of CCL-1 mRNA in kidney and spleen, sanguinarine treatment can also increase the level of transforming growth factor-β (TGF-β). In Penaeus vannamei, the anti-inflammatory effect and antibacterial activity of Macleaya Cordata extract can improve the survival rate of shrimp.

3. Basic Information of Macleaya Cordata Extract

【Product Name】Macleaya Cordata Extract

【Properties】 This product is light orange to orange powder; irritating.

[Functions and Indications] Antibacterial and anti-inflammatory, appetizing, and growth-promoting. It is used to promote the growth of pigs, chickens, ducks, freshwater fish, shrimps, crabs, turtles and soft-shelled turtles.